RAB35

Across TCGA pan-cancer cohorts, RAB35 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated RAB35 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher RAB35 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RAB35 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

PDAC, COAD, and GBM are the cancer types where RAB35 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.281	0.639	<.001	26	view →
COAD	DFS	Tertile	All	0.917	1.000	.038	12	view →
GBM	DFS	Quartile	All	0.915	0.659	.003	6	view →
CCRCC	DFS	Quartile	III,IV	0.322	0.698	.017	4	view →
LSCC	OS	Median	All	1.000	0.940	.014	4	view →
UCEC	OS	Median	All	0.984	0.912	.032	2	view →
LUAD	OS	Tertile	III,IV	0.237	0.679	.034	2	view →
HNSC	DFS	Median	III,IV	0.935	1.000	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

RAB35–PDAC (DFS)

Open the PDAC breakdown →