RAB35

Across TCGA pan-cancer cohorts, RAB35 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RAB35’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RAB35 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types RAB35 is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

HNSC, PDAC, and LUAD are the cancer types where RAB35 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAB35 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	+0.229	<.001	11	view →
PDAC	Female	II,III,IV	+0.541	<.001	9	view →
LUAD	Female	II,III,IV	−0.309	<.001	9	view →
COAD	Male	III,IV	−0.203	<.001	9	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

RAB35–HNSC

Open the HNSC breakdown →