RAB28

Across TCGA patient cohorts, RAB28 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB28-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and Cyclin-B1. Each is linked with RAB28 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB28-to-partner and partner-to-RAB28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by RAB28-low versus RAB28-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB28→partner) and Y-score (partner→RAB28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.644	+3.019	.024	.019	3	1
UCEC	4E-BP1 →	+0.442	+3.199	<.001	.009	3	1
UCEC	Cyclin-B1 →	+0.737	+2.459	.006	.020	3	1
UCEC	p62 Lck ligand →	+0.488	+3.009	.001	.019	2	1
UCEC	PKC-delta_pS664 →	-0.143	-2.459	.013	.020	2	1
UCEC	Src_pY416 →	-0.302	-3.169	.009	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Caspase-7-cleavedD198 by RAB28 expression — UCEC

Explore this box plot interactively →