RAB25

Across TCGA pan-cancer cohorts, RAB25 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RAB25 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher RAB25 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RAB25 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, UCEC, and CCRCC are the cancer types where RAB25 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	II,III,IV	0.937	0.646	.002	46	view →
UCEC	OS	Tertile	All	1.000	0.899	.014	20	view →
CCRCC	DFS	Quartile	All	0.894	0.592	.012	6	view →
HNSC	OS	Quartile	IV	1.000	0.800	.043	5	view →
LSCC	OS	Tertile	All	1.000	0.944	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RAB25–PDAC (DFS)

Open the PDAC breakdown →