RAB23

Across TCGA pan-cancer cohorts, RAB23 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RAB23 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RAB23 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RAB23 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where RAB23 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.399	0.932	.022	14	view →
PDAC	OS	Tertile	IV	0.962	0.231	.024	6	view →
HNSC	DFS	Tertile	IV	0.562	0.848	.016	4	view →
LUAD	DFS	Quartile	All	0.759	0.473	.023	3	view →
LSCC	OS	Tertile	III,IV	0.460	0.979	.017	2	view →
GBM	OS	Tertile	All	0.830	0.989	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RAB23–CCRCC (DFS)

Open the CCRCC breakdown →