RAB21

Across TCGA pan-cancer cohorts, RAB21 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated RAB21 data layer compared with 18 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher RAB21 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RAB21 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

COAD, LSCC, and PDAC are the cancer types where RAB21 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.811	1.000	.014	30	view →
LSCC	DFS	Quartile	All	1.000	0.838	.001	24	view →
PDAC	DFS	Median	All	0.323	0.489	.005	20	view →
OV	DFS	Median	All	0.553	0.938	.006	12	view →
CCRCC	DFS	Median	III,IV	0.928	0.128	.014	12	view →
HNSC	DFS	Tertile	II,III,IV	1.000	0.879	.005	11	view →
GBM	DFS	Quartile	All	0.235	0.493	.038	4	view →
UCEC	DFS	Median	All	0.936	1.000	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

RAB21–COAD (DFS)

Open the COAD breakdown →