RAB21

Across TCGA patient cohorts, RAB21 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB21-associated genes across cancer lineages are FoxM1, FOXO3a_pS318_S321, and Acetyl-a-Tubulin-Lys40. Each is linked with RAB21 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB21-to-partner and partner-to-RAB21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by RAB21-low versus RAB21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB21→partner) and Y-score (partner→RAB21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.304	+3.169	.032	.020	3	1
UCEC	FOXO3a_pS318_S321 →	-0.152	-3.160	.026	.019	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.648	+3.179	.020	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.268	-3.156	.003	.020	3	1
UCEC	Myosin-IIa_pS1943 →	+0.268	+3.183	.018	.010	3	1
UCEC	Paxillin →	+0.343	+3.169	.016	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

FoxM1 by RAB21 expression — UCEC

Explore this box plot interactively →