RAB21

Across TCGA cell cohorts, RAB21 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,013 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RAB21-associated GO terms across cancer lineages are Protein stabilization, Transcription elongation-coupled chromatin remodeling, and Endosomal transport. Each is linked with RAB21 in more than 15 cancer types. Because this analysis shows association rather than direction, both RAB21-to-partner and partner-to-RAB21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein stabilization grouped by RAB21-low versus RAB21-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB21→partner) and Y-score (partner→RAB21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Protein stabilization →	+0.055	+0.938	<.001	<.001	2	16
BLOOD_Myeloma	Transcription elongation-coupled chromatin remodeling →	+0.116	+0.705	.001	.002	3	14
BREAST	Endosomal transport →	+0.061	+1.103	<.001	<.001	3	13
BREAST	Vacuolar transport →	+0.061	+0.909	<.001	.002	3	13
STOMACH	Positive regulation of TORC2 signaling →	+0.114	+0.702	<.001	<.001	3	12
LIVER	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition →	+0.143	+0.742	.008	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,013 associations by consensus.

Protein stabilization by RAB21 expression — LARGE_INTESTINE

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