RAB20

Across TCGA patient cohorts, RAB20 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB20-associated genes across cancer lineages are MSH2, HER3_pY1289, and Annexin-1. Each is linked with RAB20 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB20-to-partner and partner-to-RAB20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by RAB20-low versus RAB20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB20→partner) and Y-score (partner→RAB20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH2 →	-0.450	-2.973	<.001	.035	3	1
UCEC	HER3_pY1289 →	+0.132	+3.026	.008	.019	1	1
UCEC	Annexin-1 →	+0.937	+3.000	.002	.037	1	1
UCEC	SF2 →	-0.201	-2.986	.001	.037	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MSH2 by RAB20 expression — UCEC

Explore this box plot interactively →