RAB1A

Across TCGA pan-cancer cohorts, RAB1A RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RAB1A’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where RAB1A RNA is repressed in tumor relative to normal tissue. In most cancer types RAB1A is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, HNSC, and KICH are the cancer types where RAB1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAB1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.082	<.001	11	view →
HNSC	All	III,IV	+0.629	<.001	11	view →
KICH	Female	II,III,IV	−1.722	<.001	8	view →
LIHC	Male	III,IV	+0.907	<.001	8	view →
LUAD	Male	II,III,IV	+0.549	<.001	7	view →
BLCA	All	All	+0.314	.004	7	view →
BRCA	All	III,IV	+0.421	<.001	6	view →
LUSC	Male	All	+0.405	<.001	5	view →
CHOL	Male	All	+1.393	<.001	4	view →
ESCA	Female	All	+1.000	.009	4	view →
STAD	All	II,III,IV	+0.362	.006	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RAB1A–THCA

Open the THCA breakdown →