RAB17

Across TCGA patient cohorts, RAB17 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB17-associated genes across cancer lineages are Caspase-7-cleavedD198, Caspase-8, and Notch1. Each is linked with RAB17 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB17-to-partner and partner-to-RAB17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by RAB17-low versus RAB17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB17→partner) and Y-score (partner→RAB17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.706	+3.169	.030	.020	3	1
UCEC	Caspase-8 →	-0.305	-3.169	.027	.020	3	1
UCEC	Notch1 →	+0.286	+3.169	<.001	.020	1	1
UCEC	Tuberin →	+0.460	+3.169	.001	.020	1	1
UCEC	C-Raf →	+0.256	+3.169	.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Caspase-7-cleavedD198 by RAB17 expression — UCEC

Explore this box plot interactively →