RAB15

Across TCGA patient cohorts, RAB15 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB15-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and FoxM1. Each is linked with RAB15 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB15-to-partner and partner-to-RAB15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by RAB15-low versus RAB15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB15→partner) and Y-score (partner→RAB15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.128	-2.394	<.001	.003	3	1
UCEC	EGFR_pY1068 →	-0.226	-2.169	.016	.003	3	1
UCEC	FoxM1 →	+0.197	+1.415	.042	.046	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.387	+1.765	.015	.014	3	1
UCEC	ACC1 →	+0.331	+2.472	.015	.010	3	1
UCEC	Heregulin →	-0.124	-1.861	.007	.049	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

14-3-3_beta by RAB15 expression — UCEC

Explore this box plot interactively →