Across TCGA patient cohorts, RAB12 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB12-associated genes across cancer lineages are Notch1, ATM, and EGFR_pY1068. Each is linked with RAB12 in more than 2 cancer types. Because this analysis shows association rather than direction, both RAB12-to-partner and partner-to-RAB12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB12→partner) and Y-score (partner→RAB12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.255	+2.700	<.001	.006	3	3
UCEC	ATM →	-0.449	-2.000	.028	.032	3	2
UCEC	EGFR_pY1068 →	-0.328	-2.700	.003	.006	3	1
UCEC	Heregulin →	-0.122	-3.000	.028	.036	3	1
UCEC	IGFBP2 →	-0.730	-3.169	.012	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.240	-2.687	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

RAB12 survival (RNA) · tumor vs normal (RNA) · all RAB12 data types