Across TCGA patient cohorts, R3HDM4 mutation is significantly associated with the RNA expression of many other genes, with 498 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible R3HDM4-associated genes across cancer lineages are NPM1P28, RNU6-674P, and LINC01363. Each is linked with R3HDM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both R3HDM4-to-partner and partner-to-R3HDM4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (R3HDM4→partner) and Y-score (partner→R3HDM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NPM1P28 →	+0.064	+4.913	.002	.002	3	2
UCEC	RNU6-674P →	+0.468	+2.801	.001	.002	3	2
UCEC	LINC01363 →	+0.136	+2.596	<.001	.002	3	2
SKCM	RNA5SP131 →	+0.361	+5.993	<.001	.001	3	2
UCEC	TIRAP →	+0.565	+3.491	.005	.002	3	1
UCEC	GUF1 →	+0.662	+3.212	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 498 associations by consensus.

Exploration

R3HDM4 survival (RNA) · tumor vs normal (RNA) · all R3HDM4 data types