Across TCGA cell cohorts, R3HDM4 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. CNS shows the largest number of these associations.

The most reproducible R3HDM4-associated genes across cancer lineages are SCGB3A2, PRAMEF20, and OR1E2. Each is linked with R3HDM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both R3HDM4-to-partner and partner-to-R3HDM4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (R3HDM4→partner) and Y-score (partner→R3HDM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SCGB3A2 →	+0.315	+4.510	.002	.001	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.012	+4.437	<.001	.004	3	1
CNS	OR1E2 →	+0.322	+4.321	<.001	.009	3	1
CNS	OR3A3 →	+0.282	+4.315	<.001	.006	3	1
CNS	OR1E1 →	+0.401	+4.321	<.001	.009	3	1
CNS	GKN2 →	+0.195	+4.169	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

R3HDM4 survival (RNA) · tumor vs normal (RNA) · all R3HDM4 data types