Across TCGA pan-cancer cohorts, R3HDM2P2 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of R3HDM2P2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where R3HDM2P2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types R3HDM2P2 is over-expressed in tumor, although a few such as KICH and ESCA show the opposite, repressed pattern.

COAD, PRAD, and KICH are the cancer types where R3HDM2P2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in R3HDM2P2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	+0.050	.013	4	view →
PRAD	All	All	+0.012	.041	2	view →
KICH	Male	All	−0.011	.028	2	view →
ESCA	Female	All	−0.030	.006	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: R3HDM2P2 RNA expression & survival · all R3HDM2P2 data types