R3HDM1

Across TCGA pan-cancer cohorts, R3HDM1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated R3HDM1 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher R3HDM1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated R3HDM1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where R3HDM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.522	0.882	<.001	36	view →
CCRCC	OS	Median	III,IV	1.000	0.511	.004	27	view →
LSCC	OS	Quartile	All	0.895	1.000	.003	15	view →
UCEC	DFS	Quartile	III,IV	1.000	0.417	.040	8	view →
HNSC	OS	Median	All	0.449	1.000	.023	7	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

R3HDM1–LUAD (DFS)

Open the LUAD breakdown →