R3HDM1

Across TCGA patient cohorts, R3HDM1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible R3HDM1-associated genes across cancer lineages are PCNA, C-Raf, and PARP_cleaved. Each is linked with R3HDM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both R3HDM1-to-partner and partner-to-R3HDM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by R3HDM1-low versus R3HDM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (R3HDM1→partner) and Y-score (partner→R3HDM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.258	+2.392	<.001	<.001	3	3
COAD	C-Raf →	+0.174	+2.841	.011	.033	3	2
SKCM	PARP_cleaved →	+0.143	+2.000	.040	.031	3	2
UCEC	JNK_pT183_Y185 →	-0.172	-2.700	.003	.006	3	2
UCEC	MEK1 →	+0.397	+2.000	.002	.003	3	2
UCEC	PRDX1 →	+0.170	+1.662	.019	.011	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

PCNA by R3HDM1 expression — UCEC

Explore this box plot interactively →