R3HDM1

Across TCGA cell cohorts, R3HDM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,217 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible R3HDM1-associated GO terms across cancer lineages are Constitutive heterochromatin formation, Regulation of microtubule-based process, and Nuclear chromosome segregation. Each is linked with R3HDM1 in more than 16 cancer types. Because this analysis shows association rather than direction, both R3HDM1-to-partner and partner-to-R3HDM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Constitutive heterochromatin formation grouped by R3HDM1-low versus R3HDM1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (R3HDM1→partner) and Y-score (partner→R3HDM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Constitutive heterochromatin formation →	+0.111	+1.148	<.001	<.001	3	17
BONE	Regulation of microtubule-based process →	+0.067	+0.881	.001	.004	3	17
KIDNEY	Nuclear chromosome segregation →	+0.103	+0.937	<.001	<.001	3	17
PANCREAS	Positive regulation of nuclear cell cycle DNA replication →	+0.136	+0.839	<.001	.001	3	17
UPPER_AERODIGESTIVE_TRACT	Chromosome segregation →	+0.120	+1.202	.001	<.001	3	17
BONE	Subtelomeric heterochromatin formation →	+0.182	+0.898	<.001	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,217 associations by consensus.

Constitutive heterochromatin formation by R3HDM1 expression — SOFT_TISSUE

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