R3HDM1

Across TCGA cell cohorts, R3HDM1 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible R3HDM1-associated genes across cancer lineages are CYP4A11, KRTAP22-2, and MTNR1B. Each is linked with R3HDM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both R3HDM1-to-partner and partner-to-R3HDM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYP4A11 grouped by R3HDM1-low versus R3HDM1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (R3HDM1→partner) and Y-score (partner→R3HDM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CYP4A11 →	+0.010	+3.714	<.001	.006	3	2
BLOOD_Myeloma	KRTAP22-2 →	+0.229	+4.807	<.001	.006	3	1
OESOPHAGUS	MTNR1B →	+0.139	+4.906	<.001	.006	3	1
BLOOD_Lymphoma	OR51I1 →	+0.286	+4.192	<.001	.003	3	1
BLOOD_Lymphoma	OR51Q1 →	+0.097	+3.927	<.001	.004	3	1
BLOOD_Lymphoma	WFDC13 →	+0.130	+3.927	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

CYP4A11 by R3HDM1 expression — BLOOD_Lymphoma

Explore this box plot interactively →