R3HCC1L

Across TCGA patient cohorts, R3HCC1L protein abundance is significantly associated with the RNA expression of many other genes, with 2,759 significant associations in total. GBM shows the largest number of these associations.

The most reproducible R3HCC1L-associated genes across cancer lineages are PCDH19, CASZ1, and PIEZO2. Each is linked with R3HCC1L in more than 2 cancer types. Because this analysis shows association rather than direction, both R3HCC1L-to-partner and partner-to-R3HCC1L results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, R3HCC1L versus PCDH19 in GBM, with a Pearson correlation of -0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (R3HCC1L→partner) and Y-score (partner→R3HCC1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PCDH19 →	-1.380	-0.330	<.001	<.001	3	3
HNSC	CASZ1 →	-0.514	-0.278	<.001	<.001	3	2
GBM	PIEZO2 →	+0.735	+0.255	<.001	<.001	3	2
HNSC	RPL21P132 →	-0.617	-0.344	.001	.008	3	2
GBM	KIAA1671 →	-0.557	-0.265	<.001	.005	3	2
HNSC	BMP7-AS1 →	-1.111	-0.463	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,759 associations by consensus.

R3HCC1L vs PCDH19 — GBM

Explore this scatter interactively →