R3HCC1L

Across TCGA patient cohorts, R3HCC1L mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible R3HCC1L-associated genes across cancer lineages are Shc_pY317, A-Raf_pS299, and p27_pT198. Each is linked with R3HCC1L in more than 2 cancer types. Because this analysis shows association rather than direction, both R3HCC1L-to-partner and partner-to-R3HCC1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by R3HCC1L-low versus R3HCC1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (R3HCC1L→partner) and Y-score (partner→R3HCC1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.160	-2.906	<.001	.001	3	3
UCEC	A-Raf_pS299 →	-0.123	-2.502	.001	.001	3	2
UCEC	p27_pT198 →	+0.088	+1.289	.009	.023	3	2
UCEC	14-3-3_beta →	-0.076	-2.195	.017	.009	3	1
UCEC	EGFR_pY1068 →	-0.203	-1.523	.011	.008	3	1
UCEC	eIF4E →	+0.148	+3.598	.027	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Shc_pY317 by R3HCC1L expression — UCEC

Explore this box plot interactively →