R3HCC1

Across TCGA pan-cancer cohorts, R3HCC1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of R3HCC1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where R3HCC1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types R3HCC1 is over-expressed in tumor, although a few such as HNSC and PDAC show the opposite, repressed pattern.

HNSC, PDAC, and LSCC are the cancer types where R3HCC1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in R3HCC1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	−0.352	<.001	8	view →
PDAC	Female	II,III,IV	−0.948	<.001	7	view →
LSCC	Male	All	−0.183	<.001	6	view →
COAD	All	II,III,IV	−0.333	.001	4	view →
LUAD	Female	All	−0.116	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

R3HCC1–HNSC

Open the HNSC breakdown →