QTRT2

Across TCGA patient cohorts, QTRT2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible QTRT2-associated genes across cancer lineages are Ku80, MEK1_p_S217_S221, and VHL. Each is linked with QTRT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both QTRT2-to-partner and partner-to-QTRT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by QTRT2-low versus QTRT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (QTRT2→partner) and Y-score (partner→QTRT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.327	+3.335	.008	.005	3	1
UCEC	MEK1_p_S217_S221 →	-0.333	-3.000	.020	.036	3	1
UCEC	VHL →	-1.047	-3.000	.003	.036	3	1
UCEC	YB-1_pS102 →	-0.257	-3.321	.008	.010	3	1
UCEC	MEK1 →	+0.524	+3.321	.006	.010	2	1
UCEC	Notch1 →	+0.211	+3.321	.004	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Ku80 by QTRT2 expression — UCEC

Explore this box plot interactively →