Across TCGA pan-cancer cohorts, QTRT1 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of QTRT1’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where QTRT1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types QTRT1 is over-expressed in tumor, although a few such as PDAC and CCRCC show the opposite, repressed pattern.

PDAC, LUAD, and LSCC are the cancer types where QTRT1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in QTRT1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	II,III,IV	−1.077	<.001	8	view →
LUAD	Male	All	+0.258	<.001	8	view →
LSCC	Male	III,IV	+0.451	<.001	7	view →
CCRCC	All	All	−0.130	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: QTRT1 RNA expression & survival · all QTRT1 data types