QSOX2

Across TCGA pan-cancer cohorts, QSOX2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated QSOX2 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher QSOX2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated QSOX2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

PDAC, HNSC, and COAD are the cancer types where QSOX2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.272	0.508	.007	31	view →
HNSC	DFS	Quartile	IV	0.954	0.562	.012	7	view →
COAD	DFS	Median	IV	0.432	0.944	.012	6	view →
UCEC	OS	Median	All	0.967	0.848	.018	4	view →
LSCC	OS	Tertile	All	0.709	1.000	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

QSOX2–PDAC (DFS)

Open the PDAC breakdown →