QSOX2

Across TCGA patient cohorts, QSOX2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible QSOX2-associated genes across cancer lineages are eEF2, JNK2, and P-Cadherin. Each is linked with QSOX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both QSOX2-to-partner and partner-to-QSOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by QSOX2-low versus QSOX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (QSOX2→partner) and Y-score (partner→QSOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.282	+2.999	.040	.035	3	2
UCEC	JNK2 →	+0.187	+3.026	.014	.018	3	2
UCEC	P-Cadherin →	-0.139	-2.321	.012	.033	3	2
UCEC	Cyclin-E2 →	+0.138	+2.009	.032	.017	3	2
UCEC	14-3-3_beta →	-0.107	-3.558	.005	.002	3	1
UCEC	EGFR_pY1068 →	-0.210	-2.584	.029	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

eEF2 by QSOX2 expression — UCEC

Explore this box plot interactively →