QSOX1

Across TCGA pan-cancer cohorts, QSOX1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of QSOX1’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where QSOX1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types QSOX1 is over-expressed in tumor, although a few such as LSCC and HNSC show the opposite, repressed pattern.

PDAC, LSCC, and HNSC are the cancer types where QSOX1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in QSOX1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Male	All	+0.914	<.001	10	view →
LSCC	Male	III,IV	−0.604	<.001	8	view →
HNSC	Male	All	−0.523	<.001	8	view →
COAD	Male	All	−0.321	<.001	8	view →
CCRCC	All	All	+0.226	.006	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

QSOX1–PDAC

Open the PDAC breakdown →