QSER1

Across TCGA pan-cancer cohorts, QSER1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated QSER1 data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher QSER1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated QSER1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

PDAC, LSCC, and UCEC are the cancer types where QSER1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	II,III,IV	0.632	0.996	.004	26	view →
LSCC	OS	Tertile	All	0.888	0.643	.009	23	view →
UCEC	DFS	Tertile	All	0.862	1.000	.006	10	view →
CCRCC	DFS	Quartile	All	0.549	1.000	.041	2	view →
LUAD	DFS	Median	III,IV	0.894	0.617	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

QSER1–PDAC (DFS)

Open the PDAC breakdown →