QSER1

Across TCGA patient cohorts, QSER1 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible QSER1-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and ARID1A. Each is linked with QSER1 in more than 4 cancer types. Because this analysis shows association rather than direction, both QSER1-to-partner and partner-to-QSER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by QSER1-low versus QSER1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (QSER1→partner) and Y-score (partner→QSER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.441	+2.019	.008	.001	3	5
BLCA	14-3-3_beta →	-0.128	-3.584	.008	.002	3	3
UCEC	ARID1A →	-0.153	-2.222	.003	.009	3	3
UCEC	C-Raf →	+0.130	+1.643	.001	.002	3	3
UCEC	Cyclin-B1 →	+0.630	+2.736	<.001	<.001	3	3
UCEC	Di-Ras3 →	-0.131	-3.156	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

Caspase-7-cleavedD198 by QSER1 expression — UCEC

Explore this box plot interactively →