QSER1

Across TCGA cell cohorts, QSER1 mutation is significantly associated with the RNA expression of many other genes, with 632 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible QSER1-associated genes across cancer lineages are C1QBP, ZNF77, and GML. Each is linked with QSER1 in more than 1 cancer types. Because this analysis shows association rather than direction, both QSER1-to-partner and partner-to-QSER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QBP grouped by QSER1-low versus QSER1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (QSER1→partner) and Y-score (partner→QSER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C1QBP →	+0.680	+3.829	.001	<.001	3	2
LARGE_INTESTINE	ZNF77 →	+0.365	+3.160	.003	.006	3	2
BLOOD_Leukemia	GML →	+0.053	+2.982	.001	.007	3	1
BLOOD_Leukemia	LHX3 →	+0.073	+4.215	.002	.001	3	1
BLOOD_Leukemia	IL22 →	+0.021	+4.247	<.001	.004	3	1
BLOOD_Leukemia	RFPL2 →	+0.164	+3.662	.006	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 632 associations by consensus.

C1QBP by QSER1 expression — LARGE_INTESTINE

Explore this box plot interactively →