QRSL1

Across TCGA pan-cancer cohorts, QRSL1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated QRSL1 data layer compared with 21 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher QRSL1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated QRSL1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and CCRCC are the cancer types where QRSL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	1.000	0.832	.004	36	view →
PDAC	OS	Median	IV	0.951	0.381	.006	9	view →
CCRCC	DFS	Tertile	All	1.000	0.748	.002	5	view →
HNSC	OS	Median	III,IV	0.793	0.568	.014	4	view →
LUAD	OS	Median	II,III,IV	0.449	0.893	.023	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

QRSL1–LSCC (DFS)

Open the LSCC breakdown →