QRSL1

Across TCGA pan-cancer cohorts, QRSL1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of QRSL1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where QRSL1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types QRSL1 is over-expressed in tumor, although a few such as CCRCC and PDAC show the opposite, repressed pattern.

CCRCC, PDAC, and COAD are the cancer types where QRSL1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in QRSL1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	II,III,IV	−0.664	<.001	12	view →
PDAC	Female	II,III,IV	−0.744	<.001	9	view →
COAD	Male	III,IV	+0.352	<.001	8	view →
LSCC	Female	All	+0.209	<.001	5	view →
LUAD	Male	All	−0.137	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

QRSL1–CCRCC

Open the CCRCC breakdown →