QRSL1

Across TCGA patient cohorts, QRSL1 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible QRSL1-associated genes across cancer lineages are INPP4B, Notch1, and Tuberin_pT1462. Each is linked with QRSL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both QRSL1-to-partner and partner-to-QRSL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by QRSL1-low versus QRSL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (QRSL1→partner) and Y-score (partner→QRSL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.393	-2.999	.020	.035	3	2
UCEC	Notch1 →	+0.169	+2.820	.022	.035	3	1
UCEC	Tuberin_pT1462 →	+0.321	+3.009	.008	.019	3	1
UCEC	Tuberin →	+0.376	+2.999	.007	.035	3	1
UCEC	ACC1 →	+0.396	+3.321	.037	.010	2	1
UCEC	MEK1 →	+0.508	+3.321	.007	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

INPP4B by QRSL1 expression — UCEC

Explore this box plot interactively →