QRICH2

Across TCGA patient cohorts, QRICH2 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible QRICH2-associated genes across cancer lineages are Rad50, Caveolin-1, and MSH2. Each is linked with QRICH2 in more than 2 cancer types. Because this analysis shows association rather than direction, both QRICH2-to-partner and partner-to-QRICH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by QRICH2-low versus QRICH2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (QRICH2→partner) and Y-score (partner→QRICH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.256	-1.688	<.001	.001	3	3
SKCM	Caveolin-1 →	-0.553	-1.807	.029	.026	3	3
BRCA	MSH2 →	+0.491	+3.321	<.001	.011	3	2
UCEC	14-3-3_beta →	-0.087	-2.060	.002	.004	3	2
UCEC	eIF4G →	+0.244	+1.688	.006	.001	3	2
UCEC	MEK1 →	+0.415	+2.415	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

Rad50 by QRICH2 expression — UCEC

Explore this box plot interactively →