QRICH2

Across TCGA cell cohorts, QRICH2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,778 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible QRICH2-associated GO terms across cancer lineages are Positive regulation of intracellular steroid hormone receptor signaling pathway, Negative regulation of gene expression, epigenetic, and U2-type prespliceosome assembly. Each is linked with QRICH2 in more than 13 cancer types. Because this analysis shows association rather than direction, both QRICH2-to-partner and partner-to-QRICH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular steroid hormone receptor signaling pathway grouped by QRICH2-low versus QRICH2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (QRICH2→partner) and Y-score (partner→QRICH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.137	+1.152	<.001	<.001	3	14
OVARY	Negative regulation of gene expression, epigenetic →	+0.060	+0.644	.004	.008	3	13
BREAST	U2-type prespliceosome assembly →	+0.106	+1.262	.001	.001	3	12
SOFT_TISSUE	Subtelomeric heterochromatin formation →	+0.111	+0.894	<.001	<.001	3	12
BREAST	Negative regulation of mRNA splicing, via spliceosome →	+0.086	+0.953	<.001	.002	3	12
OESOPHAGUS	Transport along microtubule →	+0.048	+0.806	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,778 associations by consensus.

Positive regulation of intracellular steroid hormone receptor signaling pathway by QRICH2 expression — BREAST

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