Across TCGA pan-cancer cohorts, QRICH1 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of QRICH1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where QRICH1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types QRICH1 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

COAD, CCRCC, and PDAC are the cancer types where QRICH1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in QRICH1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	+0.154	.002	5	view →
CCRCC	Male	III,IV	−0.083	.030	4	view →
PDAC	All	All	+0.138	.010	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: QRICH1 RNA expression & survival · all QRICH1 data types