QPRT

Across TCGA pan-cancer cohorts, QPRT mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated QPRT data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher QPRT mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated QPRT expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

GBM, PDAC, and LSCC are the cancer types where QPRT mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	0.374	0.698	<.001	24	view →
PDAC	DFS	Tertile	II,III,IV	0.546	0.275	.002	21	view →
LSCC	DFS	Quartile	II,III,IV	0.461	0.883	.006	10	view →
UCEC	OS	Median	II,III,IV	0.565	1.000	.004	8	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

QPRT–GBM (OS)

Open the GBM breakdown →