QPRT

Across TCGA cell cohorts, QPRT RNA expression is significantly associated with the go_rna of many other GO terms, with 4,341 significant associations in total. BONE shows the largest number of these associations.

The most reproducible QPRT-associated GO terms across cancer lineages are Quinolinate metabolic process, Alcohol biosynthetic process, and 'de novo' NAD+ biosynthetic process from L-tryptophan. Each is linked with QPRT in more than 15 cancer types. Because this analysis shows association rather than direction, both QPRT-to-partner and partner-to-QPRT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Quinolinate metabolic process grouped by QPRT-low versus QPRT-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (QPRT→partner) and Y-score (partner→QPRT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Quinolinate metabolic process →	+2.255	+4.030	<.001	<.001	3	16
BONE	Alcohol biosynthetic process →	+0.091	+2.737	.001	<.001	3	10
BONE	'de novo' NAD+ biosynthetic process from L-tryptophan →	+0.319	+2.931	<.001	<.001	3	9
KIDNEY	Dicarboxylic acid catabolic process →	+0.148	+3.318	.001	<.001	2	10
SKIN	Secondary alcohol metabolic process →	+0.069	+1.747	<.001	<.001	3	9
LIVER	Nicotinamide nucleotide biosynthetic process →	+0.208	+2.851	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,341 associations by consensus.

Quinolinate metabolic process by QPRT expression — LUNG_SCLC

Explore this box plot interactively →