QPCTL

Across TCGA pan-cancer cohorts, QPCTL mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of QPCTL’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where QPCTL mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types QPCTL is over-expressed in tumor, although a few such as PDAC and LSCC show the opposite, repressed pattern.

CCRCC, PDAC, and LSCC are the cancer types where QPCTL tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in QPCTL mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	III,IV	+0.617	<.001	11	view →
PDAC	All	All	−0.566	<.001	6	view →
LSCC	All	All	−0.114	.009	4	view →
LUAD	All	All	−0.102	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

QPCTL–CCRCC

Open the CCRCC breakdown →