QPCT

Across TCGA patient cohorts, QPCT mutation is significantly associated with the RNA expression of many other genes, with 1,146 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible QPCT-associated genes across cancer lineages are HINT1P2, RN7SL237P, and HMGB3P8. Each is linked with QPCT in more than 1 cancer types. Because this analysis shows association rather than direction, both QPCT-to-partner and partner-to-QPCT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HINT1P2 grouped by QPCT-low versus QPCT-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (QPCT→partner) and Y-score (partner→QPCT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	HINT1P2 →	+0.204	+5.758	<.001	.003	3	2
LIHC	RN7SL237P →	+0.353	+5.447	<.001	.005	3	2
LIHC	HMGB3P8 →	+0.089	+5.647	<.001	.004	3	2
LIHC	H3P11 →	+0.107	+5.186	.003	.007	3	2
LGG	KRTAP19-2 →	+0.104	+7.977	<.001	.007	3	2
LGG	TRAJ59 →	+0.537	+7.977	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,146 associations by consensus.

HINT1P2 by QPCT expression — LIHC

Explore this box plot interactively →