QPCT

Across TCGA patient cohorts, QPCT mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible QPCT-associated genes across cancer lineages are Notch1, p62 Lck ligand, and EGFR_pY1068. Each is linked with QPCT in more than 1 cancer types. Because this analysis shows association rather than direction, both QPCT-to-partner and partner-to-QPCT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by QPCT-low versus QPCT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (QPCT→partner) and Y-score (partner→QPCT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.201	+3.335	<.001	.005	3	2
UCEC	p62 Lck ligand →	+0.357	+1.884	.007	.030	3	2
UCEC	EGFR_pY1068 →	-0.289	-4.087	.005	<.001	3	1
UCEC	eIF4G →	+0.279	+2.999	.029	.035	3	1
UCEC	GATA6 →	-0.138	-2.459	.031	.019	3	1
UCEC	INPP4B →	-0.385	-2.700	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Notch1 by QPCT expression — UCEC

Explore this box plot interactively →