QDPR

Across TCGA pan-cancer cohorts, QDPR mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated QDPR data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher QDPR mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated QDPR expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, HNSC, and CCRCC are the cancer types where QDPR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	All	0.944	0.758	<.001	71	view →
HNSC	DFS	Tertile	All	0.894	1.000	.002	59	view →
CCRCC	OS	Tertile	All	0.957	0.764	.010	37	view →
UCEC	DFS	Median	III,IV	0.386	1.000	.002	32	view →
LSCC	DFS	Tertile	All	0.550	0.817	.008	15	view →
GBM	OS	Median	All	0.301	0.454	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

QDPR–PDAC (OS)

Open the PDAC breakdown →