QARS1

Across TCGA cell cohorts, QARS1 mutation is significantly associated with the mutation status of many other genes, with 4,514 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible QARS1-associated genes across cancer lineages are EPPK1, WDR62, and ZBTB20. Each is linked with QARS1 in more than 4 cancer types. Because this analysis shows association rather than direction, both QARS1-to-partner and partner-to-QARS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EPPK1 grouped by QARS1-low versus QARS1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (QARS1→partner) and Y-score (partner→QARS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	EPPK1 →	+3.023	+4.485	.001	.001	1	5
LARGE_INTESTINE	WDR62 →	+2.222	+2.925	.001	.001	1	4
OVARY	ZBTB20 →	+4.977	+4.415	.007	.007	1	4
LARGE_INTESTINE	EPB41L1 →	+2.807	+3.321	<.001	<.001	1	4
BLOOD_Lymphoma	ACTRT3 →	+5.584	+5.014	.003	.003	1	4
BLOOD_Leukemia	ACOX1 →	+4.560	+4.870	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,514 associations by consensus.

EPPK1 by QARS1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →