PYY3

Across TCGA pan-cancer cohorts, PYY3 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated PYY3 data layer compared with 9 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher PYY3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PYY3 expression acts as an unfavorable survival marker.

BLCA are the cancer types where PYY3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.069	0.710	<.001	36	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

PYY3–BLCA (OS)

Open the BLCA breakdown →