PYY3

Across TCGA patient cohorts, PYY3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,070 significant associations in total. STAD shows the largest number of these associations.

The most reproducible PYY3-associated GO terms across cancer lineages are Pancreas development, Positive regulation of chondrocyte differentiation, and Cell-substrate junction organization. Each is linked with PYY3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PYY3-to-partner and partner-to-PYY3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pancreas development grouped by PYY3-low versus PYY3-high in UCEC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PYY3→partner) and Y-score (partner→PYY3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Pancreas development →	+0.048	+0.066	<.001	<.001	3	3
UCEC	Positive regulation of chondrocyte differentiation →	+0.069	+0.032	<.001	.002	3	3
UCEC	Cell-substrate junction organization →	+0.088	+0.034	<.001	.001	3	2
UCEC	Regulation of endoplasmic reticulum unfolded protein response →	+0.075	+0.032	<.001	.002	3	2
UCEC	Positive regulation of extracellular matrix assembly →	+0.092	+0.060	<.001	.002	3	2
UCEC	Negative regulation of signal transduction by p53 class mediator →	+0.083	+0.063	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,070 associations by consensus.

Pancreas development by PYY3 expression — UCEC

Explore this box plot interactively →