PYY

Across TCGA pan-cancer cohorts, PYY Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PYY data layer compared with 20 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PYY Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PYY expression acts as an unfavorable survival marker.

HNSC, SCLC, and LUAD are the cancer types where PYY Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.122	0.696	<.001	45	view →
SCLC	OS	Median	All	0.055	0.708	<.001	36	view →
LUAD	OS	Median	All	0.017	0.812	<.001	24	view →
STAD	OS	Median	III,IV	0.153	0.632	.005	23	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PYY–HNSC (DFS)

Open the HNSC breakdown →