PYROXD2

Across TCGA patient cohorts, PYROXD2 mutation is significantly associated with the RNA expression of many other genes, with 1,559 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PYROXD2-associated genes across cancer lineages are RNU6-1187P, SLC25A28, and SNF8. Each is linked with PYROXD2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PYROXD2-to-partner and partner-to-PYROXD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1187P grouped by PYROXD2-low versus PYROXD2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYROXD2→partner) and Y-score (partner→PYROXD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-1187P →	+0.375	+4.748	.001	.003	3	3
UCEC	SLC25A28 →	+0.289	+2.279	.001	<.001	3	2
UCEC	SNF8 →	+0.334	+2.080	.001	.004	3	2
UCEC	MST1R →	+1.233	+2.321	<.001	<.001	3	2
UCEC	RCCD1 →	+0.462	+2.981	<.001	<.001	3	2
UCEC	DOLPP1 →	+0.501	+2.010	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,559 associations by consensus.

RNU6-1187P by PYROXD2 expression — LUSC

Explore this box plot interactively →