PYROXD2

Across TCGA patient cohorts, PYROXD2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PYROXD2-associated genes across cancer lineages are ERK2, MEK1, and Shc_pY317. Each is linked with PYROXD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PYROXD2-to-partner and partner-to-PYROXD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by PYROXD2-low versus PYROXD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYROXD2→partner) and Y-score (partner→PYROXD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.142	+1.736	.034	.007	3	2
UCEC	MEK1 →	+0.258	+1.906	.042	.015	3	2
UCEC	Shc_pY317 →	-0.137	-1.906	.009	.015	3	2
UCEC	14-3-3_beta →	-0.076	-2.432	.028	.018	3	1
UCEC	eIF4E →	+0.171	+2.415	.019	.003	3	1
UCEC	FOXO3a_pS318_S321 →	-0.087	-1.755	.043	.013	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

ERK2 by PYROXD2 expression — UCEC

Explore this box plot interactively →