PYROXD1

Across TCGA cell cohorts, PYROXD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,451 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PYROXD1-associated GO terms across cancer lineages are RNA splicing, via endonucleolytic cleavage and ligation, Multivesicular body assembly, and tRNA splicing, via endonucleolytic cleavage and ligation. Each is linked with PYROXD1 in more than 9 cancer types. Because this analysis shows association rather than direction, both PYROXD1-to-partner and partner-to-PYROXD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA splicing, via endonucleolytic cleavage and ligation grouped by PYROXD1-low versus PYROXD1-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PYROXD1→partner) and Y-score (partner→PYROXD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RNA splicing, via endonucleolytic cleavage and ligation →	+0.069	+0.848	.002	.001	2	10
LARGE_INTESTINE	Multivesicular body assembly →	+0.063	+0.614	.001	.003	3	8
PANCREAS	tRNA splicing, via endonucleolytic cleavage and ligation →	+0.095	+0.983	<.001	<.001	3	7
BLOOD_Myeloma	RNA exon ligation →	+0.144	+1.137	.003	.009	3	7
BLOOD_Myeloma	tRNA exon ligation →	+0.144	+1.137	.003	.009	3	7
LIVER	Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway →	+0.079	+0.691	.001	.007	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,451 associations by consensus.

RNA splicing, via endonucleolytic cleavage and ligation by PYROXD1 expression — LARGE_INTESTINE

Explore this box plot interactively →